Mechanisms by which I B proteins control NF- B activity
نویسندگان
چکیده
منابع مشابه
-Arrestin inhibits NF- B activity by means of its interaction with the NF- B inhibitor I B
In addition to their roles in desensitization and signaling of seven-membrane-spanning receptors, -arrestins have been more recently implicated in regulating non-seven-membrane-spanning receptor pathways. By using a yeast two-hybrid screen, we identified the inhibitor of NFB, I B , as a binding partner of -arrestin 1. Both -arrestin 1 and 2 interact with I B in transfected cells as assessed by ...
متن کاملBeyond I Bs: alternative regulation of NF- B activity
The transcription factor nuclear factorkappa B (NFB) is a crucial regulator of many physiological and patho-physiological processes, including control of the adaptive and innate immune responses, inflammation, proliferation, tumorigenesis, and apoptosis. Thus, the tight regulation of NFB activity within a cell is extremely important. The central mechanism of NFregulation is the signal-induced p...
متن کاملA firm hand on NF B: structures of the I B –NF B complex
The regulation of gene expression, which allows a living cell to express a defined set of genes according to its environmental conditions and stage of development, occurs primarily at the level of transcription. The precise temporal and spatial control of the transcription factor NFκB has become a paradigm for the complexity of transcriptional regulation in eukaryotes. IκB, the inhibitor and ce...
متن کاملProlyl hydroxylase - 1 negatively regulates I B kinase - , giving insight into hypoxia - induced NF B activity
Hypoxia is a feature of the microenvironment of a growing tumor. The transcription factor NF B is activated in hypoxia, an event that has significant implications for tumor progression. Here, we demonstrate that hypoxia activates NF B through a pathway involving activation of I B kinase(IKK ) leading to phosphorylationdependent degradation of I B and liberation of NF B. Furthermore, through inc...
متن کاملI B -dependent regulation of low-shear flow-induced NF- B activity: role of nitric oxide
Sumathy Mohan,1 Masao Hamuro,1 George P. Sorescu,5 Koichi Koyoma,1 Eugene A. Sprague,2 Hanjoong Jo,5 Anthony J. Valente,3 Thomas J. Prihoda,1 and Mohan Natarajan4 Departments of 1Pathology, 2Radiology, 3Medicine, and 4Radiation Oncology, University of Texas Health Science Center, San Antonio, Texas 78229; and 5Wallace H. Coulter Department of Biomedical Engineering at Georgia Tech and Emory Uni...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 1999
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.96.1.49